Risedronate reduces bone loss
نویسندگان
چکیده
منابع مشابه
Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.
Human breast cancer frequently metastasizes to the skeleton to cause osteolysis and subsequent pain, pathological fracture, and hypercalcemia. Because bone continuously releases growth factors stored in bone matrix by bone resorption during physiological remodeling and, thus, possibly provides a favorable microenvironment for metastatic breast cancer cells to proliferate, inhibitors of bone res...
متن کاملBreast Cancer Burden in Bone in Nude Mice Bisphosphonate Risedronate Reduces Metastatic Human
Human breast cancer frequently metastasizes to the skeleton to cause osteolysis and subsequent pain, pathological fracture, and hypercalcemia. Because bone continuously releases growth factors stored in bone matrix by bone résorptionduring physiological remodeling and, thus, possibly provides a favorable microenvironment for metastatic breast cancer cells to proliferate, inhibitors of bone ré...
متن کاملEffect of pre- and post-surgery treatment with risedronate on trabecular bone loss in ovariectomized rats.
The purposes of the present study were to differentiate the effects of pre-surgery treatment with risedronate and post-surgery treatment with a reduced dosing frequency of risedronate on trabecular bone loss in ovariectomized rats and to determine whether post-surgery treatment with a reduced dosing frequency of risedronate would have a beneficial effect on trabecular bone loss after pre-surger...
متن کاملEffect of risedronate on high-dose corticosteroid-induced bone loss in patients with glomerular disease.
BACKGROUND Corticosteroids are often used for the treatment of glomerular diseases. We examined whether bisphosphonate or vitamin D3 has beneficial effects on bone mineral density (BMD) in patients with glomerular diseases being treated with high-dose corticosteroids, including pulse therapy. METHODS Thirty-eight patients (19 men and 19 women, aged 42 +/- 16 years) were randomized into three ...
متن کاملProtective effect of low-dose risedronate against osteocyte apoptosis and bone loss in ovariectomized rats
Osteocyte apoptosis is the first reaction to estrogen depletion, thereby stimulating osteoclastic bone resorption resulting in bone loss. We investigated the effects of two different risedronate (RIS) doses (high and low) on osteocyte apoptosis, osteoclast activity and bone loss in ovariectomized rats. Forty rats with ovariectomy (OVX) and sham ovariectomy (SHAM) were divided into 4 groups: 1) ...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2014
ISSN: 1759-4774,1759-4782
DOI: 10.1038/nrclinonc.2014.214